Centrosomes and tumour suppressors.

Control of virus infection by tumour suppressors.

An increasing number of tumour suppressor genes are induced by interferons (IFNs) and may play an important role in the control of cell proliferation induced by this cytokine. In addition, pathways triggered by both tumour suppressors and IFN converge as common targets for non-related tumour viruses. The inhibition of the IFN response by animal viruses is explained by the fundamental role that ...

The Role of Suppressors of Cytokine Signalling in Human Neoplasms

Suppressors of cytokine signalling 1-7 (SOCS1-7) and cytokine-inducible SH2-containing protein (CIS) are a group of intracellular proteins that are well known as JAK-STAT and several other signalling pathways negative feedback regulators. More recently several members have been identified as tumour suppressors and dysregulation of their biological roles in controlling cytokine and growth factor...

MicroRNAs and lncRNAs as Tumour Suppressors

BRCA1 is associated with the centrosome during mitosis.

Centrosomes and their associated microtubules direct events during mitosis and control the organization of animal cell structures and movement during interphase. The centrosome replicates during the cell cycle, directs the assembly of bipolar mitotic spindles, and plays an important role in maintaining the fidelity of cell division. Recently, tumor suppressors such as p53 and retinoblastoma pro...

CNIO Cancer Conference Animal Tumour Models and Functional Genomics

s-Sessions Session I: Stem Cells and Cancer 17 Session II: Functional Genomics and Cancer Targets 24 Session III: Oncogenes and Tumour Suppressors 29 Session IV: Genetic Instability 37 Session V: Invasion and Metastasis 42